Detall de la convocatòria

Expressió d'interès - Expression of interest

Característiques

Característica
Objectiu de la convocatòria
1 year grants to support research related to GNAO1 Neurodevelopmental Disrder
Característiques principals
GNAO1 is a protein-coding gene associated with a neurodevelopmental disorder diagnosed in infancy or early childhood. Symptoms include refractory seizures, abnormal movements, and developmental delays, often worsening with age. Deep brain stimulation surgery has helped some patients, including a 2-year-old in the UK.
The Orphan Disease Center and Bow Foundation are funding research to advance understanding and treatment of GNAO1 disorders. Focus areas include:
  • Developing novel therapies (e.g., genome editing, RNA-based methods, biologics, and small molecule repurposing).
  • Collaborative projects across organizations or diseases.
  • Establishing outcome measures for clinical trials.
  • Supporting clinical, preclinical, and animal model trials targeting drug repurposing.
  • Other aims are welcome and will be considered
  • Additional innovative proposals are also encouraged.
    • Lloc de presentació
    HMRIB and PSMAR staff who need more information should contact::
    Research Grants and Contracts Office. C/ Doctor Aiguader, 88. 08003-Barcelona. Tel.: 93.316.04.00.
    Carol Barnwell: cbarnwell@researchmar.net Ext.: 1670
    Marta López: mlopez4@researchmar.net Ext.: 1576
    Convocatòria (URL)
    https://www.orphandiseasecenter.med.upenn.edu/grants/bowfoundationloi-a532l
    Requisits
    All individuals holding a faculty-level appointment at an academic institution or a senior position at a non-profit institution or foundation are eligible to respond to this RFA.
    Dotació
    One-year grants to support research related to GNAO1 Neurodevelopmental Disorder:
    At least 2 awards will be granted at $100,000 each.
    Documentació
    The application requires a cover page, biosketches or CVs (5 pages max) for the PI and key personnel, and a detailed budget with justifications. A 5-page research plan must outline aims, background, methods, and resource access, accompanied by a 1-page bibliography. An appendix (5 pages max) can include supplemental data, reprints, and relevant approval or support letters.
    AVÍS IMPORTANT
    This is a two stage application, with a Letter of Intent, and a Full Proposal. However, the full proposal is due just 2 weeks after the LOI, so be sre to prepare both with plenty of time.

    Arxius

    Arxiu
    RFA+Bow+Foundation+II+Grant+Program+2025+FINAL.pdf