Detall de la convocatòria

Expressió d'interès - Expression of interest

Característiques

Característica
Objectiu de la convocatòria
This grant program supports research aimed at elucidating the molecular and cellular mechanisms of marstacimab–TFPI interactions, including, but not limited to, differential tissue expression of tissue factor and TFPI, binding kinetics, and other biochemical properties.
Característiques principals
Clinical Area: Haemophilia and Other Bleeding Disorders

Projects should focus on basic science and the fundamental biological understanding of Tissue Factor Pathway Inhibitor (TFPI), anti-TFPI monoclonal antibodies, and marstacimab, including, but not limited to:
  • Basic biology of TFPI, including interactions among key regulatory proteins within the intrinsic and/or extrinsic coagulation cascades (e.g. Protein S as a cofactor for both Protein C and TFPI)
  • Impact of differential TFPI expression across tissues and the role of different TFPI pools/isoforms in coagulation regulation
  • Pharmacology effects of concomitant therapies administered alongside anti-TFPI treatments
    • Lloc de presentació
    HMRIB and PSMAR staff who need more information should contact:
    Research Grants and Contracts Office. C/ Doctor Aiguader, 88. 08003 Barcelona. Tel.: 93.316.04.00.
    Carol Barnwell: [email protected] Ext.: 1670
    Marta López: [email protected] Ext.: 1576
    Júlia Vidal: [email protected] Ext.: 1736
    Convocatòria (URL)
    https://cdn.pfizer.com/pfizercom/2026-05/2026-RD-G-RareBleedingTFPIPathways-RES.pdf
    Requisits
  • The PI must have a medical or postdoctoral degree (MD, PhD, or equivalent), an advanced nursing degree (BSN with a MS/PhD), or a degree in Pharmacy, Physiotherapy, or Social Work.
  • The applicant must be the project/program lead—or an authorized designee—and must be an employee or contractor of the requesting organization.
  • Only organizations can receive grants; individuals are not eligible.
  • The institution and PI must be based in one of the following countries: Brazil, China, Germany, Italy, Japan, Netherlands, Saudi Arabia, South Korea, Spain, Turkey, UK, or the USA.
  • For collaborative projects, whether within a single institution or across multiple organizations, all partners must have relevant roles, and the requesting organization must play a key role.
    • Dotació
    $50,000
    Durada
    1 year

    Arxius

    Arxiu
    2026-RD-G-RareBleedingTFPIPathways-RES.pdf